abstract：:Assuming that the experience of strong aversive tension might be an indicator of the extent of affect dysregulation within patients with borderline personality disorder (BPD), we sought to operationalize the duration and intensity of these phenomena. In addition we studied the relationship between aversive tension and...

journal_title：Journal of psychiatric research

authors： Stiglmayr CE,Shapiro DA,Stieglitz RD,Limberger MF,Bohus M

更新日期：2001-03-01 00:00:00

abstract：:Several lines of evidence suggest a dysregulation of the adrenocortical (HPA) system with hypersecretion of CRH is associated with suicidal behavior. However, controversial results have emerged from the determination of corticotropin-releasing hormone (CRH) concentrations in the lumbar cerebrospinal fluid (CSF) of sui...

journal_title：Journal of psychiatric research

authors： Brunner J,Stalla GK,Stalla J,Uhr M,Grabner A,Wetter TC,Bronisch T

更新日期：2001-01-01 00:00:00

abstract：:Benzodiazepine hypnotics increase NREM sleep and alter its EEG by reducing delta (0.3-3 Hz) and increasing sigma (12-15 Hz) and beta (15-23 Hz) activity. We tested whether the nonbenzodiazepine hypnotic, zolpidem (10 mg), produced the same pattern of sleep and EEG changes as two "classical" benzodiazepines, triazolam ...

journal_title：Journal of psychiatric research

authors： Feinberg I,Maloney T,Campbell IG

更新日期：2000-11-01 00:00:00

abstract：:In previous studies of schizophrenic patients, neuromuscular (histopathological and electrophysiological) and psychomotor (finger tapping) abnormalities were found. The present study was designed to investigate relationships between these abnormalities and a family history of psychosis in 14 schizophrenic patients and...

journal_title：Journal of psychiatric research

authors： Flyckt L,Wiesel FA,Borg J,Edman G,Ansved T,Sydow O,Borg K

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:To investigate the role of the dopamine receptor 3 (DRD3) and transporter 1 (DAT1) genes in schizophrenia or in modulating its phenotype. METHODS:a Ser9Gly polymorphism in codon 9 of the DRD3 and a VNTR polymorphism in the DAT1genes were examined in two groups of schizophrenic patients, one of excellent neur...

journal_title：Journal of psychiatric research

authors： Joober R,Toulouse A,Benkelfat C,Lal S,Bloom D,Labelle A,Lalonde P,Turecki G,Rouleau GA

更新日期：2000-07-01 00:00:00

abstract：:The auditory evoked field (AEF) component N100m represents the most prominent and stable peak of the AEF, and its alterations in patients with schizophrenia are an extensive topic of neuropsychiatric research. In our current study, the degree of N100m habituation was investigated in 20 male schizophrenics and 19 healt...

journal_title：Journal of psychiatric research

authors： Rosburg T,Kreitschmann-Andermahr I,Nowak H,Sauer H

更新日期：2000-05-01 00:00:00

abstract：:Previous studies have reported abnormalities either in the cAMP-dependent endogenous phosphorylation or in the levels of Rap1 in platelets from bipolar patients. One limitation of these findings was that they come from different groups of patients in independent studies. To overcome this limitation, we designed the pr...

journal_title：Journal of psychiatric research

authors： Perez J,Tardito D,Mori S,Racagni G,Smeraldi E,Zanardi R

更新日期：2000-03-01 00:00:00

abstract：:Neural cell adhesion molecule (N-CAM) is a cell recognition molecule, four major isoforms (180, 140, 120, and 105-115 kDa) of which are present in brain. N-CAM has several roles in cellular organization and CNS development. Previously we have found an elevation in CSF N-CAM 120 kDa in the CSF of patients with schizoph...

journal_title：Journal of psychiatric research

authors： Vawter MP,Frye MA,Hemperly JJ,VanderPutten DM,Usen N,Doherty P,Saffell JL,Issa F,Post RM,Wyatt RJ,Freed WJ

更新日期：2000-01-01 00:00:00

abstract：:The concept that schizophrenia has its antecedents in neurodevelopment has long been debated and has been at the forefront of research on this disorder over the last decade. However new recent evidence from controlled longitudinal studies indicates that some of the structural brain anomalies observed in schizophrenia ...

journal_title：Journal of psychiatric research

authors： DeLisi LE

更新日期：1999-11-01 00:00:00

abstract：:The purpose of the study was to examine ethnic influences on sleep regulation. Seventy-three normal volunteers from four ethnic groups (17 African-Americans, 10 Asians, 30 Caucasians and 16 Hispanics) were studied for two consecutive nights with sleep polysomnography recordings in the laboratory. The subjects were in ...

journal_title：Journal of psychiatric research

authors： Rao U,Poland RE,Lutchmansingh P,Ott GE,McCracken JT,Lin KM

更新日期：1999-09-01 00:00:00

abstract：:A substantial number of studies have demonstrated increased imidazoline receptors (I1 binding sites) on platelets of depressed patients and downregulation following antidepressant treatments. Herein, imidazoline receptor binding protein (IRBP) antiserum was used to quantify imidazoline receptors on platelets of depres...

journal_title：Journal of psychiatric research

authors： Zhu H,Halaris A,Madakasira S,Pazzaglia P,Goldman N,DeVane CL,Andrew M,Reis D,Piletz JE

更新日期：1999-07-01 00:00:00

abstract：:Previous studies of gender differences in the phenomenology of depression have focused mostly on symptoms as measured by self-report questionnaires or clinician-rated scales. In this study, we examined gender differences in the interpersonal behavior of depressed patients by using ethological techniques which involve ...

journal_title：Journal of psychiatric research

authors： Troisi A,Moles A

更新日期：1999-05-01 00:00:00

abstract：:Drop-out is a common phenomenon in clinical trials of drug treatments involving longitudinal assessments for a fixed duration of follow-up. For these trials intent-to-treat (IT) analysis is usually preferred because time effects are seen in practice. The IT analysis mandates that all subjects randomized to a treatment...

journal_title：Journal of psychiatric research

authors： Mazumdar S,Liu KS,Houck PR,Reynolds CF 3rd

更新日期：1999-03-01 00:00:00

abstract：:Utilizing the DSM-III-R schema, we have investigated lifetime comorbidity between panic disorder with or without agoraphobia (PD), social phobia (SP) and obsessive-compulsive disorder (OCD) on the one hand, and mood disorder on the other. Compared with PD, the results for SP and OCD showed significantly higher numbers...

journal_title：Journal of psychiatric research

authors： Perugi G,Akiskal HS,Ramacciotti S,Nassini S,Toni C,Milanfranchi A,Musetti L

更新日期：1999-01-01 00:00:00

abstract：:In a group of 242 community-dwelling patients with Alzheimer's disease (AD), a longitudinal comparison was made of two caregiver-administered instruments for assessment of behavioral disturbance; the Cohen-Mansfield Agitation Inventory (CMAI) and the CERAD Behavioral Rating Scale for Dementia (BRSD). We examined recor...

journal_title：Journal of psychiatric research

authors： Weiner MF,Koss E,Patterson M,Jin S,Teri L,Thomas R,Thal LJ,Whitehouse P

更新日期：1998-11-01 00:00:00

abstract：:The purpose of this study was to delineate differences in inpatient service utilization and functional and subjective outcomes between veterans with a serious mental illness (SMI) and those with co-occurring serious mental illnesses and substance abuse (SA) disorders. This study assessed 2-year inpatient utilization a...

journal_title：Journal of psychiatric research

authors： Blow FC,Barry KL,BootsMiller BJ,Copeland LA,McCormick R,Visnic S

更新日期：1998-09-01 00:00:00

abstract：:By examining the literature concerning early intervention with antipsychotic medications, and how it affects long-term morbidity, this article will review the concept that early intervention with antipsychotic medications improves the long-term course of schizophrenia. It also looks at the potential long-term effects ...

journal_title：Journal of psychiatric research

authors： Wyatt RJ,Henter ID

更新日期：1998-05-01 00:00:00

abstract：:The level of platelet monoamine oxidase (MAO) activity has been found to vary between alcoholics and healthy controls and between subtypes of alcoholics, in different populations. This study measured the MAO activity in a group of 46 abstinent alcohol dependent subjects and 22 healthy non-alcoholic controls, male and ...

journal_title：Journal of psychiatric research

authors： Farren CK,Clare AW,Tipton KF,Dinan TG

更新日期：1998-01-01 00:00:00

abstract：:Immune factors may be involved in the pathophysiology of Alzheimer's disease (AD), a neurodegenerative disease. Since immune activation precedes immune-mediated processes, we measured plasma levels of four selective cytokines: interleukin-6 (IL-6), interleukin-12 (IL-12), interferon-alpha (IFN-alpha), and interferon-g...

journal_title：Journal of psychiatric research

authors： Singh VK,Guthikonda P

更新日期：1997-11-01 00:00:00

abstract：:This article describes the use of the NIMH prospective life-charting methodology (NIMH LCM-p) in the context of a formal double-blind, clinical trial and provides preliminary evidence of its reliability and validity. Subjects included in this report were 30 outpatients with bipolar I and II disorder who completed the ...

journal_title：Journal of psychiatric research

authors： Denicoff KD,Smith-Jackson EE,Disney ER,Suddath RL,Leverich GS,Post RM

更新日期：1997-09-01 00:00:00

abstract：:Mood disorders may be associated with global and regional changes in cerebral blood flow and metabolism. The accumulated functional neuroimaging findings in mood disorders were reviewed in order to examine a proposed neuroanatomic model of pathophysiology. Global cerebral blood flow and glucose metabolism appear norma...

journal_title：Journal of psychiatric research

authors： Soares JC,Mann JJ

更新日期：1997-07-01 00:00:00

abstract：:Sleep deprivation (SD) is an effective, however short-lived, method of treatment of depression. Preliminary findings suggest that the antidepressive effect of sleep deprivation is mediated by serotoninergic (5-HT) mechanisms. We therefore assessed serotoninergic activity before and after total SD (TSD) as well as afte...

journal_title：Journal of psychiatric research

authors： Schreiber W,Opper C,Dickhaus B,Heiser P,Wesemann W,Krieg JC

更新日期：1997-05-01 00:00:00

abstract：:Glutamate and GABA are the principle neurotransmitters of the cerebral cortex and are known to modulate dopaminergic function. Evidence of structural abnormalities in the cortex raises the possibility that schizophrenia involves disturbances of cortical amino-acid neurotransmission. The psychotomimetic effects of phen...

journal_title：Journal of psychiatric research

authors： Deakin JF,Simpson MD

更新日期：1997-03-01 00:00:00

abstract：:To examine the influence of mode of illness onset on psychiatric status and neuropsychological performance, 36 patients with CFS were divided into two groups: sudden vs gradual onset of symptoms. These two CFS subgroups were compared to each other and to sedentary healthy controls on standardized neuropsychological te...

journal_title：Journal of psychiatric research

authors： DeLuca J,Johnson SK,Ellis SP,Natelson BH

更新日期：1997-01-01 00:00:00

abstract：:Binocular depth inversion represents an illusion of visual perception. Such inversion does not occur in all cases, especially when objects with a higher degree of familiarity (e.g. photographs of faces) are displayed. Cognitive factors are assumed to override the binocular disparity cues of stereopsis. We tested the h...

journal_title：Journal of psychiatric research

authors： Schneider U,Leweke FM,Niemcyzk W,Sternemann U,Bevilacqua M,Emrich HM

更新日期：1996-11-01 00:00:00

abstract：:The personality profile of 26 adult migraine patients from a large Swedish family with migraine and 87 controls were studied by means of Cloninger's seven-factor model of Temperament and Character (TCI; Temperament and Character Inventory). For the diagnosis of migraine, a questionnaire, slightly modified to fit the c...

journal_title：Journal of psychiatric research

authors： Nylander PO,Schlette P,Brändström S,Nilsson M,Forsgren T,Forsgren L,Adolfsson R

更新日期：1996-09-01 00:00:00

abstract：:Several lines of evidence indicate that alterations in intracellular calcium homeostasis with sustained elevation of free calcium ions ([Ca2+]i) might be important in the pathophysiology of Alzheimer's disease (AD). Recent studies with peripheral blood-cells have demonstrated that investigation of regulatory mechanism...

journal_title：Journal of psychiatric research

authors： Bondy B,Hofmann M,Müller-Spahn F,Witzko M,Hock C

更新日期：1996-05-01 00:00:00

abstract：:This study explored the effect of elevated systemic cortisol levels on plasma epinephrine and norepinephrine, and hemodynamic variables, in patients with active Cushing's syndrome; ratings of depressed mood were also obtained. Norepinephrine levels were significantly negatively correlated with 24 h urinary free cortis...

journal_title：Journal of psychiatric research

authors： Cameron OG,Starkman MN,Schteingart DE

更新日期：1995-09-01 00:00:00

abstract：:In a study designed to assess the effects of short-term food deprivation on cognitive function, a sample of female subjects (N = 21) was tested on a number of measures of cognitive function after three levels of food deprivation (miss one meal, miss two meals or miss all food for 24 h prior to testing) and a condition...

journal_title：Journal of psychiatric research

authors： Green MW,Elliman NA,Rogers PJ

更新日期：1995-05-01 00:00:00

abstract：:Primary care patients with infrequent panic attacks were found to have similar levels of disability in their social, family and vocational functioning to patients who met DSM-III-R criteria for panic disorder. Both panic subgroups had significantly more functional disability than controls. Patients with panic and infr...

journal_title：Journal of psychiatric research

authors： Katon W,Hollifield M,Chapman T,Mannuzza S,Ballenger J,Fyer A

更新日期：1995-03-01 00:00:00

abstract：:Lumbar puncture was performed on 12 healthy female volunteers at the L4-5 level. CSF concentrations of 5-HIAA, HVA and HMPG were included in turn as dependent variables in repeated analyses of covariance with age, height, tapping-time, atmospheric pressure and the distance on the spine in the lying position as regress...

journal_title：Journal of psychiatric research

authors： Eklundh T,Fernström V,Nordin C

更新日期：1994-11-01 00:00:00

abstract：:Using a psychiatrically referred, depressed, school-age sample, we sought to cross-validate the clinically pertinent epidemiologic finding that the distribution of age at onset of first episode of major depressive disorder (MDD) is subject to birth-cohort and period effects. Demographic and historical variables also w...

journal_title：Journal of psychiatric research

authors： Kovacs M,Gatsonis C

更新日期：1994-05-01 00:00:00

abstract：:Although cut-points or threshold scores are commonly used in screening instruments as well as in psychiatric diagnostic practice, much is still to be learned about their functional characteristics. This study demonstrates that, for a cut-off of y items on a screening instrument, there is great variability in the ident...

journal_title：Journal of psychiatric research

authors： Clarke DM,McKenzie DP

更新日期：1994-03-01 00:00:00

abstract：:'Behavioral contagion' refers to an increased tendency for a behavior to be performed when socially related persons have already performed it. So understood, behavioral contagion may be involved in criminality, conduct disorder, drug abuse, suicide, and teenage pregnancy. In a recent paper we showed that contagion, wh...

journal_title：Journal of psychiatric research

authors： Jones MB,Jones DR

更新日期：1994-01-01 00:00:00

abstract：:In a prospective study of a random sample of 1,007 young adults, we examined the association between migraine and psychiatric disorder, physical complaints, indicators of functional impairment, and use of mental health services. A history of migraine was associated with increased lifetime rates of major depression, an...

journal_title：Journal of psychiatric research

authors： Breslau N,Davis GC

更新日期：1993-04-01 00:00:00

abstract：:The purpose of the present study was to assess and compare the therapeutic effects of imipramine during the initial treatment and retreatment of panic disorder with agoraphobia patients. Seven women with panic disorder with agoraphobia who had shown a marked and stable response to imipramine (121.4 +/- 41.8 mg/day) du...

journal_title：Journal of psychiatric research

authors： Mavissakalian MR,Perel JM,de Groot C

更新日期：1993-01-01 00:00:00

abstract：:The objective of this report is to determine whether those patients with panic disorder who have current major depression disorder (MDD) differ from those who do not in terms of demographics, comorbid disorders, severity of illness, nature of symptoms of panic attacks and psychosocial functioning. The sample consisted...

journal_title：Journal of psychiatric research

authors： Reich J,Warshaw M,Peterson LG,White K,Keller M,Lavori P,Yonkers KA

更新日期：1993-01-01 00:00:00

abstract：:Drug treatment of panic disorder with benzodiazepines and antidepressants has been established as efficacious in the short-term (6-8 weeks). The efficacy of medications during long-term (i.e., continuous) treatment has not often been addressed and a review of the evidence is presented. Most data exists for the long-te...

journal_title：Journal of psychiatric research

authors： Burrows GD,Judd FK,Norman TR

更新日期：1993-01-01 00:00:00

abstract：:We summarize here our findings with respect to attentional impairment among offspring of schizophrenic, affectively ill, and normal parents followed from childhood to adulthood during the two decades of the New York High-Risk Project (NYHRP). We review our data first, on childhood attentional performance in each of ou...

journal_title：Journal of psychiatric research

authors： Erlenmeyer-Kimling L,Cornblatt BA

更新日期：1992-10-01 00:00:00

abstract：:A brief overview is given of the history of psychiatric nosology during the last 150 years. The varying role of genetics for theories of nosology is described. Classifications of mental disorders, more or less based on nosological concepts, are mentioned, as well as the recent emphasis on operational tools for classif...

journal_title：Journal of psychiatric research

authors： Strömgren E

更新日期：1992-10-01 00:00:00